The GT HapScreen HBB kit is developed to detect Beta Thalassemia. The kit functions on the principle based on STR markers and QF-PCR technique to detect carrier or to be patient by linkage analysis. Use of STR markers makes prenatal diagnosis more accurate and reliable.
The kit components include multiplex PCR primers which are designed from a HBB gene. This gene is used commonly in carrier detection and prenatal diagnosis of Beta-Thalassemia disease. STR markers designed from 5 regions that covers the upstream and downstream of the HBB gene.
GT HapScreen HBB is optimized to use DNA samples purified from blood, amniotic fluid, and chorionic villus (CVS).
Along with Beta-Thalassemia detection the GT-HapScreen HBB kit includes autosomal STR markers for Chromosome 21, 18, 13, X and Y. These markers provide extra advantages along with detection of this disorder, viz;
- Avoidance of sample cross-contamination
- Ruling out maternal cell contamination
- Paternity testing
- Chromosomal aneuploidy detection