Why is this test important?
Male infertility is a critical health problem that affects 8 – 12% of reproductive-aged couples worldwide. Male infertility contributes to about 20 – 30% of these cases, out of which 5 – 10% are caused by Y chromosome microdeletions.
The science behind the GT-AZFScreen
Microdeletions in the long arm of the Y chromosome can cause spermatogenic failure. The critical region for spermatogenesis is the azoospermia factor (AZF), the deletion of which causes azoospermia. Four loci AZFa, AZFb, AZFc and AZFd required for normal spermatogenesis, are located in the AZF regions. Diagnosing the major cause of azoospermia is an initial and important step in the treatment process for infertile men. Since this kind of Y chromosome microdeletion can cause different phenotypes, accurate diagnosis is a very important step in the treatment process.